Matthew Breen :: PhD :: C.Biol :: FRSB ::
Professor of Genomics and the Oscar J. Fletcher Distinguished Professor of Comparative Oncology Genetics

Lab Publications

2004

  • Breen, M ., Hitte, C., Lorentzen, T., Thomas, R., Cadieu, E., Sabacan, L., Scott, A., Evanno, G., Parker, H.G., Kirkness, E., Hudson, R., Guyon, R., Mahairas, G.G., Gelfenbeybn, B., Fraser, C.M., André, C., Galibert, F., Ostrander, E.A. (2004). An Integrated 4300 Marker FISH/RH Map of the Canine Genome. BMC Genomics 5:65, 1-11 [PUBMED LINK]
  • Fosmire, S.P., Dickerson, E.B., Scott, A., Bianco, S.R., Pettengill, M., Meylemans, H., Padilla, M., Frazer-Abel, A.A., Akhtar, N., Getzy, D.M., Wojcieszyn, J., Breen, M., Helfand, S.C., Modiano, J.F. (2004). Canine Malignant Hemangiosarcoma as a Model of Primitive Angiogenic Endothelium. Lab Invest. 84, 562-572. [PUBMED LINK]
  • Akhtar, N, Padilla, M.L., Dickerson, E.B., Steinberg, H., Breen, M., Auerbach, R., Helfand, S.C. (2004). Interleuikin-12 inhibits tumor growth in a novel angiogenesis canine hemangiosarcom xenograft model. Neoplasia 6, 106-116 [PUBMED LINK]
  • Comstock, K.E., Lingaas, F., Kirkness E.F, Hitte, C., Thomas, R., Breen, M., Moe, L, Galibert, F., Ostrander, E.A. (2004). A High Resolution Map of Canine Chromosome 5q14.3-33 Spanning Human Chromosome 17p11.2 Utilizing the 1.5 x Canine Genome Sequence. Mammalian Genome 15:544-551. [PUBMED LINK]
  • Fosmire, S.P., Dickerson, E.B., Scott, A., Bianco, S.R., Pettengill, M., Meylemans, H., Padilla, M., Frazer-Abel, A.A., Akhtar, N., Getzy, D.M., Wojcieszyn, J., Breen, M., Helfand, S.C., Modiano, J.F. (2004). Canine Malignant Hemangiosarcoma as a Model of Primitive Angiogenic Endothelium. Lab Invest. 84, 562-572. [PUBMED LINK]
  • Akhtar, N, Padilla, M.L., Dickerson, E.B., Steinberg, H., Breen, M., Auerbach, R., Helfand, S.C. (2004). Interleuikin-12 inhibits tumor growth in a novel angiogenesis canine hemangiosarcom xenograft model. Neoplasia 6, 106-116 [PUBMED LINK]

2003

  • Thomas, R., Fiegler, H., Ostrander, E.A., Galibert, F., Carter, N.P., Breen, M. (2003). A canine cancer gene microarray for CGH analysis of canine tumors. Cytogenetic and Genome Research 102:254-260.
  • Thomas, R, Bridge, W., Benke, K., Breen, M. (2003). Isolation, characterization and chromosomal localization of 25 cancer related canine genes. Cytogenetic and Genome Research 102:249-253.
  • Olby, N., Blot, S., Thibaud, J.L., Phillips, J.,Burr, J., Berg, J., Brown, T., Breen, M. Cerebellar cortical degeneration in adult American Staffordshire terriers. American Journal Veterinary Internal Medicine 18, 201-208. [PUBMED LINK]
  • Rak, S.G., Drogemuller, C., Leeb, T., Quignon,P., Andre, C., Scott, A, Breen, M., Distl. O. (2003) Cloning and chromosomal assignment of 20 candidate genes for canine congenital sensorineural deafness by FISH and RH mapping. Cytogenetic and Genome Research 101:130-135.
  • Lingaas, F., Comstock, K.E., Kirkness E.F., Sorensen, A., Aarskaug, T., Hitte, C., Nickerson, M,L, Moe, L, Schmidt, L.S., Thomas, R., Breen, M., Galibert, F., Zbar, B., Ostrander, E.A. A Mutation in the Canine BHD Gene is Associated with Hereditary Multifocal Renal Cystadenocarcinoma and Nodular Dermatofibrosis in the German Shepherd Dog. Human Molecular Genetics 12:3043-3053. [PUBMED LINK]
  • Langford, C.F. and Breen, M. (2003). Chromosome Structure and Function - Comparative Cytogenetics. In: Nature Encyclopedia of the Human Genome. Macmillan Publishers Ltd. Nature Publishing Group, Hampshire, U.K. http://www.ehgonline.net/
  • Tiret, L., Blot, S., Kessler, J.L., Gaillot, H., Breen, M., Panthier, J.J. (2003). Mapping of the cnm locus in Labrador retrievers, a canine homologue of the human autosomal forms of the centronuclear myopathy. Human Genetics 113:297-306. [PUBMED LINK]
  • Thomas, R., Smith, K.C., Ostrander, E.A., Galibert, F., Breen, M. (2003). Chromosome Aberrations in Canine Multicentric Lymphomas Detected with Comparative Genomic Hybridisation and a Panel of Single Locus Probes. British Journal of Cancer 89:1530-1537.
  • Spriggs, H.F., Holmes, N.G., Breen, M., Deloukas, P., Langford, C.F., Ross, M.T., Carter, N.P., Davis, M.E., Knights, C.E., Smith, A.E., Farr. C.J., McCarthy, L.C., Binns, M.M. (2003). Construction and integration of radiation-hybrid and cytogenetic maps of dog Chromosome X. Mammalian Genome 14(3):214-221. [PUBMED LINK]

2002

  • Breen, M. (2002). Equine clinical cytogenetics - human chromosomes sitting on horse chromosomes. (Invited Leader) Equine Veterinary Journal 34:110-111.
  • Breen, M., Switonski, M., Binns, M.M. (2001). Cytogenetics and Physical Chromosome Maps: Chapter 11 in Genetics of the Dog. Ruvinsky and Sampson- eds. CAB International, Oxon, U.K.
  • Breen, M., Jouquand S., Renier C., Mellersh C.S., Hitte C., Holmes N.G. , Cheron A., Suter N., Vignaux F., Bristow A.E., Priat C ., McCann E., Andre C., Boundy S., Gitsham P., Thomas R., Bridge W.L., Spriggs H.F., Ryder E.J., Curson A., Sampson J., Ostrander E.A., Binns M.M., and Galibert F. (2001). Chromosome-specific single locus FISH probes allow anchorage of an 1,800 marker integrated radiation-hybrid/ linkage map of the domestic dog (Canis familiaris) genome to all chromosomes. Genome Research 11:1784-1796.

Selected Pre-2002

  • Thomas, R., Smith, K.C., Gould, R., Gower, S.M., Binns, M.M., Breen, M. (2001). Molecular cytogenetic analysis of a novel high-grade T-lymphoblastic lymphoma demonstrating co-expression of CD3 and CD79a cell markers. Chromosome Research 8: 649-657.
  • Thomas, R., Breen, M., Deloukas, P., Holmes, N.G. and Binns, M.M (2001). An integrated physical, comparative and radiation-hybrid map of dog chromosome five. Mammalian Genome 12: 371-375.
  • Dunn, K.A., Thomas, R., Binns, M.M., Breen, M. (2000). Comparative Genomic Hybridisation (CGH) in Dogs - Application to the study of a Canine Glial Tumour Cell Line. The Veterinary Journal 160(1): 77-82.
  • Leeb, T., Neumann, S., Deppe, A., Breen, M., Brenig, B. (2000). Genomic organization of the dog dystroglycan gene (DAG) locus on chromosome 20q15.1-q15.2. Genome Research 10:295-301.
  • Binns, M.M., Swinburne, J.E., Breen, M. (2000). Molecular Genetics. Chapter 6 in 'Horse Genetics' , CAB International, Oxon, U.K. -ed A.T. Bowling.
  • Thomas, R., Breen, M., Langford, C.F., and Binns, M.M. (1999). Zoo-FISH analysis of dog chromosome 5: identification of conserved synteny with human and cat chromosomes. Cytogenetics and Cell Genetics 87:4-10.
  • Breen, M., Thomas, R., Binns, M.M., Carter, N.P. and Langford, C.F (1999). Reciprocal chromosome painting reveals detailed regions of synteny between the karyotypes of the domestic dog (Canis familiaris) and human. Genomics 61:145-155.
  • Breen, M., Bullerdiek, J and Langford, C. (1999). The DAPI banded karyotype of the domestic dog (Canis familiaris) generated using chromosome specific paint probes. Chromosome Research 7:401-406 [+erratum vol 7:575]
  • Schatzberg, S.J., Olby, N.J., Breen, M., Anderson, L.V.B., Langford, C.F., Dickens, H.F., Wilton, S.D., Zeiss, C.J., Binns, M.M., Kornegay, J.N.,Morris, G., Sharp, N.J.H. (1999). Molecular analysis of a spontaneous dystrophin 'knockout' dog. Neuromuscular Disorders 9:289-295.
  • van der Sluis, B.J.A., Breen, M., Nanji, M., van Wolferen, M., de Jong, P., Binns, M.M., Pearson, P.L., Kuipers, J., Rothuizen, J., Cox, D.W.,Wijmenga, C., van Oost, B. (1999). Genetic mapping of the copper toxicosis locus in Bedlington terriers to dog chromosome 10, in a region syntenic to human chromosome region 2p13-16. Human Molecular Genetics 8:501-507.
  • Breen, M., Langford, C.F., Carter, N.P., Holmes, N.G., Dickens, H.F., Thomas, R., Suter, N., Ryder, E.J., Pope, M. and Binns, M.M. (1999). FISH mapping and identification of canine chromosomes. Journal of Heredity 90:27-30.