breen lab @ ncsu

Selected Publications

 

Click here to be directed to a list of lab publications and abstracts at PUBLICATIONSLIST.ORG

Supplementary on line materials - CLICK HERE

 

 

2012

• Antoine Italiano, Rachael Thomas, Matthew Breen, Aimee Crago, Samuel Singer, Raya Khanin, Robert G Maki, Markus Hafner, Tom Tuschl, Cristina R. Antonescu. The miR-17-92 cluster microRNAs and its target THROMBOSPONDIN-1 are differentially expressed in angiosarcomas dependent on MYC amplification. Genes, Chromosome, Cancer (in press).

• Daisuke Ito, Aric Frantz, Christina Williams, Rachael Thomas, Robert C. Burnett, Anne C. Avery, Matthew Breen, Nicola J. Mason, Timothy D. O’Brien and Jaime F. Modiano. CD40 ligand is necessary and sufficient to support primary diffuse large B-cell lymphoma cells in culture: a tool for in vitro preclinical studies with primary B-cell malignancies Leukemia and Lymphoma (in press).

2011

• Venugopal Thayanithy, Aaron L. Sarver, Reena V. Kartha, ChangWon Park, Milcah Scott, Andrea C. Young, Matthew Breen, Clifford J. Steer, Jaime F. Modiano and Subbaya Subramanian (2011). Perturbation in 14q32 miRNAs-MYC-miR-17~92 gene network contributes to osteosarcoma and is associated with survival outcome. Bone (in press) 
• Josely F. Figueiredo*, Sarah Culver*, Erica Behling-Kelly, Matthew Breen, Kristen Friedrichs (2011). Acute Myeloblastic leukemia with associated BCR-ABL translocation in a dog. Veterinary Clinical Pathology (in press). [* joint 1st authors]
• Eric L. Seiser, Rachael Thomas, Kristy L. Richards, M. Kathryn Kelley, Peter Moore, Steven E. Suter and Matthew Breen (2011). Reading Between the Lines: Molecular Characterization of Five Widely Utilized Canine Lymphoid Tumor Cell Lines. Veterinary and Comparative Oncology (in press).
• Tsai, P. C. and Breen, M. aCGH-guided identification of suitable reference genes for real-time quantitative PCR analysis in canine tumors. AJVR (in press).
• Jessica Alföldi, Federica Di Palma, Manfred Grabherr, Christina Williams, Lesheng Kong, Evan Mauceli, Pamela Russell, Craig B. Lowe, Richard Glor, Jacob D. Jaffe, David A. Ray, Stephane Boissinot, Andrew M. Shedlock, Christopher Botka, Todd A. Castoe, John K. Colbourne, Matthew K. Fujita, Ricardo Godinez Moreno, Boudewijn F. ten Hallers, David Haussler, Andreas Heger, David Heiman, Daniel E. Janes, Jeremy Johnson, Pieter J. de Jong, Maxim Y. Koriabine, Peter Novick, Chris L. Organ, Sally E. Peach, Steven Poe, David D. Pollock, Kevin de Queiroz, Thomas Sanger, Steve Searle, Jeremy D. Smith, Zachary Smith, Ross Swofford, Jason Turner-Maier, Juli Wade, Sarah Young, Amonida Zadissa, Genome Sequencing Platform and Whole Genome Assembly Team, Scott V. Edwards, Travis C. Glenn, Christopher J. Schneider, Jonathan B. Losos, Eric S. Lander, Matthew Breen, Chris P. Ponting, Kerstin Lindblad-Toh (2011). The genome of the green anole lizard and a comparative analysis with birds and mammals. Nature doi:10.1038/nature10390. Jounal Link
• Shannon E Duke Becker, Rachael Thomas, Vladimir A Trifonov, Robert K Wayne, Alexander S Graphodatsky, Matthew Breen. (2011). Anchoring the dog to its relatives reveals new evolutionary breakpoints across 11 species of the Canidae and provides new clues for the role of B chromosomes. Chromosome Research 19: 685-708 (Journal link)
• Andrea Y. Angstadt, Alison Motsinger-Reif, Rachael Thomas, William C. Kisseberth, C. Guillermo Couto, Dawn L. Duval, Dahlia M. Nielsen, Jaime F. Modiano, and Matthew Breen. (2011). Characterization of canine osteosarcoma by array comparative genomic hybridization and RT-qPCR: signatures of genomic imbalance in canine osteosarcomaparallel the human counterpart. Genes, Chromosomes, Cancer 50:859-874.
• Benoit Hedan, Rachael Thomas, Alison Motsinger-Reif, Jérôme Abadie, Catherine André, John Cullen and Matthew Breen (2011). Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior. BMC Cancer, 11:201.
• Milcah C Scott, Aaron L Sarver, Katherine J Gavin, Venugopal Thayanithy, David M Getzy, Robert A Newman, Gary R Cutter, Kerstin Lindblad-Toh, William C Kisseberth, Lawrence E Hunter, Subbaya Subramanian, Matthew Breen, Jaime F. Modiano, (2011). Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach. Bone 49:356-367. PUBMED LINK
• Nanda K. Thudi, Sherry T. Shu, Chelsea K. Martin, Lisa G. Lanigan, Murali V.P. Nadella, Adrie vanBokhoven, Jillian L. Werbeck, Simmons K. Jessica, Sridhar Murahari, William C. Kisseberth, Matthew Breen, Christina Williams, Ching-Shih Chen, Laurie K. McCauley, Evan T. Keller, Thomas J. Rosol.(2011). Development of a brain metastatic canine prostate cancer cell line. Prostate 71:1251-1263. PUBMED LINK
• Thomas, R., E. L. Seiser, A. A. Motsinger-Reif, L. Borst, V. E. Valli, K. Kelley, S. E. Suter, D. Argyle, K. Burgess, J. Bell, K. Lindblad-Toh, J. F. Modiano and M. Breen (2011). "Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin’s lymphomas." Leukemia and Lymphoma 52(7):1321-1335. PUBMED LINK
• Suter, S, Small, G.W., Seiser, E.L., Thomas, R, Breen, M, Richards, K.L. (2011). FLT3 mutations in canine acute lymphocytic leukemia. BMC Cancer 11:38. PUBMED LINK
• Cruz Cardona, J., Milner, R., Alleman, A.R., Williams, C., Vernau, W, Breen, M., Tompkins, M. (2011), BCR-ABL translocation in a dog with chronic monocytic leukemia. Veterinary Clinical Pathology 40:(1): 40-47[journal link] PUBMED LINK

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2010

• Ying Zheng, Arben Nace, Wei Chen, Krystal Watkins, Luke Sergott, Ying Homan, John L. Vandeberg, Matthew Breen, and Kurt Stenn (2010). Mature Hair Follicles Generated from Dissociated Cells: A Universal Mechanism of Folliculoneogenesis. Developmental Dynamics 239:2619-2626.[PUBMED LINK]
• Breen, M.  (2010). Clinical Genomics. Textbook of Veterinary Internal Medicine, Seventh Edition. Eds Ettinger and Feldman, Elsevier Chapter 6, p 28-30.
• Modiano, J.F. and Breen, M. (2010). Genetic Basis of Cancer. In Cancer management in Small Animal Practice. Henry, C. Ed. Saunders. Chapter 2, p10-15.
• Reitman ZJ, Olby NJ, Mariani CL, Thomas R, Breen M, Bigner DD, McLendon RE, Yan H. (2010). IDH1 and IDH2 hotspot mutations are not found in canine glioma. Int J Cancer. 127(1):245-246.

2009

• Thomas, R., Valli, V.E., Ellis, P., Bell, J., Karlsson, E.K., Cullen, J., Lindblad-Toh, K., Langford, C.F., Breen, M. Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas Chromosome Research 17:8 987-1000. [PUBMED LINK]
• Thomas, R, Rebbeck, C., Leroi, A.M., Burt, A, Breen, M. (2009). Extensive conservation of genomic imbalances in canine transmissible venereal tumors (CTVT) detected by microarray-based CGH analysis. Chromosome Research 7(17):927 - 934. [PUBMED LINK]
• Clare A. Rebbeck, Rachael Thomas, Matthew Breen, Armand M. Leroi,  Austin Burt. Origins and Evolution of a Transmissible Cancer. Evolution 63(9):2340-2349 [PUBMED LINK]
• Breen, M. (2009). Update on Genomics in Veterinary Oncology. Topics in Companion Animal Medicine. 24(3) 113-121. [PUBMED LINK]
• Rachael Thomas, Shannon E. Duke, Huixia J. Wang, Tessa E. Breen, Robert J. Higgins, Keith E. Linder, Peter Ellis, Cordelia F. Langford, Peter J. Dickinson, Natasha J. Olby and Matthew Breen (2009). ‘Putting our heads together’  - insights into genomic conservation between human and canine intracranial tumors. Journal of NeuroOncology 94(3):333-349 [PUBMED LINK]
• Thomas, R, Wang, H.J., Tsai, P.C., Langford, C.F., Fosmire,S.P., Jubala, C.M., Getzy, D.M., Cutter, G.R., Modiano, J.F., Breen, M. (2009). Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma. Chromosome Research 17:365-377. [PUBMED LINK]
• Tzu-yin Lin, Rachael Thomas, Pei-Chien Tsai, Matthew Breen, Cheryl A London (2009). Generation and characterization of a novel canine malignant mast cell line, CL1. Veterinary Immunology and Immunopathology 127:114-124. [PUBMED LINK]

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2008

• Thomas, R., Duke, S.E., Karlsson, E.K., Evans, A., Ellis, P., Lindblad-Toh, K., Langford, C.F. and Breen, M. (2008). A genome assembly-integrated dog 1Mb BAC microarray: a cytogenetic resource for canine cancer studies and comparative genomic analysis. Cytogenetics and Genome Research 122:110-121. [PUBMED LINK]
• Young, A.C., Kirkness, E. and Breen, M. (2008). Tackling the characterization of canine chromosomal breakpoints with an integrated in-situ/in-silico approach: The canine PAR and PAB. Chromosome Research 16:1193-1202 [PUBMED LINK]
• Modiano, J. F. and M. Breen (2008). Shared pathogenesis of human and canine tumors - an inextricable link between cancer and evolution. Cancer Therapy (6) 239-246.
• Breen, M. Canine cytogenetics - from band to basepair. Cytogenet Genome Res 2008;120:50-60 [PUBMED LINK]
• Zaunbrecher GM, Dunne PW, Mir B, Breen M, Piedrahita JA. (2008). Enhancement of extra chromosomal recombination in somatic cells by affecting the ratio of homologous recombination (HR) to non-homologous end joining (NHEJ). Anim Biotechnol. 2008;19(1):6-21. [PUBMED LINK]
• Breen. M and Langford, C.F. (2008). Chromosome Structure and Function - Comparative Cytogenetics. In: Encyclopedia of the Human Genome. Macmillan Publishers Ltd. Nature Publishing Group, Hampshire, U.K.
• Breen, M. and Modiano, J. (2008). Evolutionarily Conserved Cytogenetic Changes in Hematologic Malignancies of Dogs and Humans – Man and his best friend share more than companionship. Chromosome Research 16:145–154. [PUBMED LINK]

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2007

• Thomas, R., Duke, S. Bloom, S., Breen, T,Feiste, E., Young, A., Seiser, E., Tsai, Pei Chien, Ellis, P., Langford, C, Karlsson, E., Mauceli, E., Lindblad-Toh, K., Breen. M. (2007). A cytogenetically characterized, genome anchored 10Mb BAC array for the domestic dog. J. Heredity 98 (5): 474-484. [PUBMED LINK]
• Fosmire SP, Thomas R, Jubala CM, Smith T, Wojcieszyn J, Getzy DM, Valli VEO, Helfand SC, Cutter GC, Breen M, Modiano JF. (2007). Inactivation of p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin T cell lymphoma. Vet Path. 44(4): 467-478 [PUBMED LINK] *co-senior authors
• WC Kisseberth, P Nadella, M Breen, R Thomas, S Duke, CE Kosarek, S Murahari, W Vernau, AC Avery, MJ Burkhard, and TJ Rosol (2007). A novel canine lymphoma cell line: A translational and comparative model for lymphoma research. Leukemia Research 12:1709-1720. [PUBMED LINK]
• Modiano JF, Breen M, Valli VEO, Wojcieszyn, J.W, Cutter, G. (2007). Predictive Value of p16 or Rb Inactivation in a Model of Naturally Occurring Canine non-Hodgkin Lymphoma. Leukemia 21(1): 184-187. [PUBMED LINK]
• Tarjei S. Mikkelsen, Matthew J. Wakefield, Bronwen Aken, Chris T. Amemiya, Jean L. Chang, Shannon Duke (..and others), Matthew Breen, Paul B. Samollow, Eric S. Lander & Kerstin Lindblad-Toh (2007). Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature 447, 167-177 [PUBMED LINK]
• Duke, S., Samallow, P., Mauceli, E., Lindblad-Toh, K., Breen, M. (2007). Cytogenetic BAC map of the genome of Monodelphis domestica.Chromosome Research 15:3610-370 [PUBMED LINK] *(Companion paper to the Monodelphis genome paper)
• Davidow, L.S., Breen, M., Samollow, P.B., Duke, S.E., McCarrey, J.R. and Lee, J.T. (2007). The Search for a Marsupial XIC Reveals a Break with Vertebrate Synteny. Chromosome Research 15:137-146. [PUBMED LINK] (Companion paper to the Monodelphis genome paper)
• Modiano JF and Breen M (2007). Genetic Factors in Cancer Etiology. Ch 1, p3-12 In Small Animal Clinical Oncology, 4th edition. Withrow SJ and Vail DM, eds. Elsevier: New York.

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2006

• Khanna, C. Lindblad-Toh, K., Vail, D. London, C. Bergamn, P. Barber, L. Breen, M., Kitchell, B., McNeil, E., Modiano, J.F., Niemi, S., Comstack, K.E., Ostrander, E., Westmoreland, S., Withrow S. 2006. The dog as a cancer model. Nature Biotech. (Letter to the Editor) 24:1065-6. [PUBMED LINK]
• Modiano JF, Breen M, Lana SE, Ehrhart EJ, Schaack J, Duke RC, Cutter GC, Bellgrau D (2006). Naturally occurring translational models for development of cancer gene therapy. Gene Therapy and Molecular Biology 10, 31-40, 2006
• Modiano JF and Breen M. Genetic Factors in Cancer Etiology. In Small Animal Clinical Oncology, 4th edition. Withrow SJ and Vail DM, eds. Elsevier: New York, 2006.

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2005

• Breen, M. and Thomas, R. Karyotype and Chromosomal Organization. In The Dog and its Genome. Ostrander EA, Giger U, Lindblad-Toh K, eds. Cold Spring Harbor Press:Cold Spring Harbor, 2005.
• Modiano JF, Breen M, London CA, Avery AC. Breed Specific Canine Lymphoproliferative Diseases. In The Dog and its Genome. Ostrander EA, Giger U, Lindblad-Toh K, eds. Cold Spring Harbor Press:Cold Spring Harbor, 2005.
• Rachael Thomas, Allyson Scott, Cordelia F. Langford, Susan P. Fosmire, Cristan M. Jubala, Travis D. Lorentzen, Christophe Hitte, Elinor K. Karlsson, Ewen Kirkness, Elaine A. Ostrander, Francis Galibert, Kerstin Lindblad-Toh, Jaime F. Modiano, and Matthew Breen. Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors. Genome Res. 2005;15 1831-1837 [PUBMED LINK]
• Kerstin Lindblad-Toh, Claire M Wade, Tarjei S. Mikkelsen, Elinor K. Karlsson, David B. Jaffe, Michael Kamal, Michele Clamp, Jean L. Chang, Edward J. Kulbokas, III, Michael C. Zody, Evan Mauceli, Xiaohui Xie, Matthew Breen, Robert K. Wayne, Elaine A. Ostrander, Chris P. Ponting, Francis Galibert, Douglas R. Smith, Pieter J. deJong, Ewen Kirkness, Pablo Alvarez, Tara Biagi, William Brockman, Jonathan Butler, Chee-Wye Chin, April Cook, James Cuff, Mark J. Daly, David DeCaprio, Sante Gnerre, Manfred Grabherr, Manolis Kellis, Michael Kleber, Carolyne Bardeleben, Leo Goodstadt, Andreas Heger, Christophe Hitte, Lisa Kim, Klaus-Peter Koepfli, Heidi G. Parker, John P. Pollinger, Stephen M. J. Searle, Nathan B. Sutter, Rachael Thomas and Caleb Webber, Broad Sequencing Platform members and Eric S. Lander . Genome sequence, comparative analysis and haplotype structure of the domestic dog, Nature 438, pp 803-819 - 8 December 2005. [PUBMED LINK]
• Jaime F. Modiano, Matthew Breen, Robert C. Burnett, Heidi G. Parker, Seidu Inusah, Rachael Thomas, Paul R. Avery, Kerstin Lindblad-Toh, Elaine A. Ostrander, Gary C. Cutter, and Anne C. Avery. Distinct B-Cell and T-Cell Lymphoproliferative Disease Prevalence among Dog Breeds Indicates Heritable Risk, Cancer Research 65: 5654-5661 - July 1st 2005. [PUBMED LINK]
• Dickerson, E.B., Thomas, R, Fosmire, S.P., Scott, A., Bianco, S.R., Wojcieszyn, J., Pettengill, M., Breen, M., Helfand, S.C., Modiano. J.F. (2005). Mutations of PTEN in Canine Hemangiosarcoma J. Vet Path 42 618-632. [PUBMED LINK]
• Thomson, S.A., Kennerly, E., Olby, N., Mickelson, J.R., Hoffmann, D.E., Dickinson, P.J., Gibson, G., Breen. M. (2005) Microarray analysis of differentially expressed genes of primary tumors in the canine central nervous system. J. Vet. Path. 42 550-558. [PUBMED LINK]
• Kennerly, E., Thomson, S, Olby, N., Breen, M., Gibson, G. Comparison of regional gene expression differences ion the brains of the domestic dog and human. Human Genomics 2004 Nov;1(6):435-43. [PUBMED LINK]

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2004

• Breen, M ., Hitte, C., Lorentzen, T., Thomas, R., Cadieu, E., Sabacan, L., Scott, A., Evanno, G., Parker, H.G., Kirkness, E., Hudson, R., Guyon, R., Mahairas, G.G., Gelfenbeybn, B., Fraser, C.M., André, C., Galibert, F., Ostrander, E.A. (2004). An Integrated 4300 Marker FISH/RH Map of the Canine Genome. BMC Genomics 5:65, 1-11 [PUBMED LINK]
• Fosmire, S.P., Dickerson, E.B., Scott, A., Bianco, S.R., Pettengill, M., Meylemans, H., Padilla, M., Frazer-Abel, A.A., Akhtar, N., Getzy, D.M., Wojcieszyn, J., Breen, M., Helfand, S.C., Modiano, J.F. (2004). Canine Malignant Hemangiosarcoma as a Model of Primitive Angiogenic Endothelium. Lab Invest. 84, 562-572. [PUBMED LINK]
• Akhtar, N, Padilla, M.L., Dickerson, E.B., Steinberg, H., Breen, M., Auerbach, R., Helfand, S.C. (2004). Interleuikin-12 inhibits tumor growth in a novel angiogenesis canine hemangiosarcom xenograft model. Neoplasia 6, 106-116 [PUBMED LINK]
• Comstock, K.E., Lingaas, F., Kirkness E.F, Hitte, C., Thomas, R., Breen, M., Moe, L, Galibert, F., Ostrander, E.A. (2004). A High Resolution Map of Canine Chromosome 5q14.3-33 Spanning Human Chromosome 17p11.2 Utilizing the 1.5 x Canine Genome Sequence. Mammalian Genome 15:544-551. [PUBMED LINK]
• Fosmire, S.P., Dickerson, E.B., Scott, A., Bianco, S.R., Pettengill, M., Meylemans, H., Padilla, M., Frazer-Abel, A.A., Akhtar, N., Getzy, D.M., Wojcieszyn, J., Breen, M., Helfand, S.C., Modiano, J.F. (2004). Canine Malignant Hemangiosarcoma as a Model of Primitive Angiogenic Endothelium. Lab Invest. 84, 562-572. [PUBMED LINK]
• Akhtar, N, Padilla, M.L., Dickerson, E.B., Steinberg, H., Breen, M., Auerbach, R., Helfand, S.C. (2004). Interleuikin-12 inhibits tumor growth in a novel angiogenesis canine hemangiosarcom xenograft model. Neoplasia 6, 106-116 [PUBMED LINK]

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2003

• Thomas, R., Fiegler, H., Ostrander, E.A., Galibert, F., Carter, N.P., Breen, M. (2003). A canine cancer gene microarray for CGH analysis of canine tumors. Cytogenetic and Genome Research 102:254-260.
• Thomas, R, Bridge, W., Benke, K., Breen, M. (2003). Isolation, characterization and chromosomal localization of 25 cancer related canine genes. Cytogenetic and Genome Research 102:249-253.
• Olby, N., Blot, S., Thibaud, J.L., Phillips, J.,Burr, J., Berg, J., Brown, T., Breen, M. Cerebellar cortical degeneration in adult American Staffordshire terriers. American Journal Veterinary Internal Medicine 18, 201-208. [PUBMED LINK]
• Rak, S.G., Drogemuller, C., Leeb, T., Quignon,P., Andre, C., Scott, A, Breen, M., Distl. O. (2003) Cloning and chromosomal assignment of 20 candidate genes for canine congenital sensorineural deafness by FISH and RH mapping. Cytogenetic and Genome Research 101:130-135.
• Lingaas, F., Comstock, K.E., Kirkness E.F., Sorensen, A., Aarskaug, T., Hitte, C., Nickerson, M,L, Moe, L, Schmidt, L.S., Thomas, R., Breen, M., Galibert, F., Zbar, B., Ostrander, E.A. A Mutation in the Canine BHD Gene is Associated with Hereditary Multifocal Renal Cystadenocarcinoma and Nodular Dermatofibrosis in the German Shepherd Dog. Human Molecular Genetics 12:3043-3053. [PUBMED LINK]
• Langford, C.F. and Breen, M. (2003). Chromosome Structure and Function - Comparative Cytogenetics. In: Nature Encyclopedia of the Human Genome. Macmillan Publishers Ltd. Nature Publishing Group, Hampshire, U.K. http://www.ehgonline.net/
• Tiret, L., Blot, S., Kessler, J.L., Gaillot, H., Breen, M., Panthier, J.J. (2003). Mapping of the cnm locus in Labrador retrievers, a canine homologue of the human autosomal forms of the centronuclear myopathy. Human Genetics 113:297-306. [PUBMED LINK]
• Thomas, R., Smith, K.C., Ostrander, E.A., Galibert, F., Breen, M. (2003). Chromosome Aberrations in Canine Multicentric Lymphomas Detected with Comparative Genomic Hybridisation and a Panel of Single Locus Probes. British Journal of Cancer 89:1530-1537.
• Spriggs, H.F., Holmes, N.G., Breen, M., Deloukas, P., Langford, C.F., Ross, M.T., Carter, N.P., Davis, M.E., Knights, C.E., Smith, A.E., Farr. C.J., McCarthy, L.C., Binns, M.M. (2003). Construction and integration of radiation-hybrid and cytogenetic maps of dog Chromosome X. Mammalian Genome 14(3):214-221. [PUBMED LINK]

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2002

• Breen, M. (2002). Equine clinical cytogenetics - human chromosomes sitting on horse chromosomes. (Invited Leader) Equine Veterinary Journal 34:110-111.
• Breen, M., Switonski, M., Binns, M.M. (2001). Cytogenetics and Physical Chromosome Maps: Chapter 11 in Genetics of the Dog. Ruvinsky and Sampson- eds. CAB International, Oxon, U.K.
• Breen, M., Jouquand S., Renier C., Mellersh C.S., Hitte C., Holmes N.G. , Cheron A., Suter N., Vignaux F., Bristow A.E., Priat C ., McCann E., Andre C., Boundy S., Gitsham P., Thomas R., Bridge W.L., Spriggs H.F., Ryder E.J., Curson A., Sampson J., Ostrander E.A., Binns M.M., and Galibert F. (2001). Chromosome-specific single locus FISH probes allow anchorage of an 1,800 marker integrated radiation-hybrid/ linkage map of the domestic dog (Canis familiaris) genome to all chromosomes. Genome Research 11:1784-1796.

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Selected Pre-2002

• Thomas, R., Smith, K.C., Gould, R., Gower, S.M., Binns, M.M., Breen, M. (2001). Molecular cytogenetic analysis of a novel high-grade T-lymphoblastic lymphoma demonstrating co-expression of CD3 and CD79a cell markers. Chromosome Research 8: 649-657.
• Thomas, R., Breen, M., Deloukas, P., Holmes, N.G. and Binns, M.M (2001). An integrated physical, comparative and radiation-hybrid map of dog chromosome five. Mammalian Genome 12: 371-375.
• Dunn, K.A., Thomas, R., Binns, M.M., Breen, M. (2000). Comparative Genomic Hybridisation (CGH) in Dogs - Application to the study of a Canine Glial Tumour Cell Line. The Veterinary Journal 160(1): 77-82.
• Leeb, T., Neumann, S., Deppe, A., Breen, M., Brenig, B. (2000). Genomic organization of the dog dystroglycan gene (DAG) locus on chromosome 20q15.1-q15.2. Genome Research 10:295-301.
• Binns, M.M., Swinburne, J.E., Breen, M. (2000). Molecular Genetics. Chapter 6 in 'Horse Genetics' , CAB International, Oxon, U.K. -ed A.T. Bowling.
• Thomas, R., Breen, M., Langford, C.F., and Binns, M.M. (1999). Zoo-FISH analysis of dog chromosome 5: identification of conserved synteny with human and cat chromosomes. Cytogenetics and Cell Genetics 87:4-10.
• Breen, M., Thomas, R., Binns, M.M., Carter, N.P. and Langford, C.F (1999). Reciprocal chromosome painting reveals detailed regions of synteny between the karyotypes of the domestic dog (Canis familiaris) and human. Genomics 61:145-155.
• Breen, M., Bullerdiek, J and Langford, C. (1999). The DAPI banded karyotype of the domestic dog (Canis familiaris) generated using chromosome specific paint probes. Chromosome Research 7:401-406 [+erratum vol 7:575]
• Schatzberg, S.J., Olby, N.J., Breen, M., Anderson, L.V.B., Langford, C.F., Dickens, H.F., Wilton, S.D., Zeiss, C.J., Binns, M.M., Kornegay, J.N.,Morris, G., Sharp, N.J.H. (1999). Molecular analysis of a spontaneous dystrophin 'knockout' dog. Neuromuscular Disorders 9:289-295.
• van der Sluis, B.J.A., Breen, M., Nanji, M., van Wolferen, M., de Jong, P., Binns, M.M., Pearson, P.L., Kuipers, J., Rothuizen, J., Cox, D.W.,Wijmenga, C., van Oost, B. (1999). Genetic mapping of the copper toxicosis locus in Bedlington terriers to dog chromosome 10, in a region syntenic to human chromosome region 2p13-16. Human Molecular Genetics 8:501-507.
• Breen, M., Langford, C.F., Carter, N.P., Holmes, N.G., Dickens, H.F., Thomas, R., Suter, N., Ryder, E.J., Pope, M. and Binns, M.M. (1999). FISH mapping and identification of canine chromosomes. Journal of Heredity 90:27-30.

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